Fisetin acts as an antioxidant, increases GSH, maintains mitochondrial function in the presence of oxidative stress, has anti-inflammatory activity against microglial cells, and inhibits the activity of 5-lipoxygenase, signifying that fisetin causes reduction in the age-related decline in brain function. It also has anti-inflammatory activity. Fisetin has been suggested to perform its role in suppressing tumor growth by regulating DNA and apoptosis. May delay aging, reduce depression and anxiety, improve memory, improve skin health by improving collagen, reducing UV damage, help with eczema, a skin disease, may protect the brain and improve cognitive health, control blood sugar. Fisetin has also shown neuroprotective benefits in animal models of Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and other brain pathologies, reducing the severity of disease and improving cognitive function.
