TMG gives us more energy and relieves fatigue as it helps with the mitochondria's function. The folate compound is more bioavailable and better absorbed than the common folic acid. I take it daily with niacin on some days and find that it gets me through the day even when effects from caffeine wear off. Once a day is sufficient and any excessive amount is flushed out through the urine, so there's no worry about over dosing it.

Have used this a few times especially since another brand we were using (see reviews) is no longer available (DMG - which is similar to TMG). Kirkman Labs does make good products & overall we are fine with it but the results didn't seem to be as good, though the known "side effects" weren't there as well (read up - DMG & TMG are good for men who may have issues & may consider seeking a "blue pill"; it helps for blood flow, to the brain but also other parts of the body...). We tried using this with our child who is on the spectrum to help improve brain function but the other brand we used before had better results. Still one may consider this as an alternative option if you can't find any DMG.

Added this to my nad booster regime after reading articles on the importance of methylation and how nad boosters might deplete the important methyl that we need in our body. Coupled with folate, this makes the tmg product a complete supplement compared to others.

The best quality around if you look for the specific folinic acid (not folic acid), which is the best form to absorb this ingredient. Size is a bit large to swallow but manageable, convenient package, neutral taste. Folinic acid may protect against bone marrow suppression or gastrointestinal mucosa inflammation. Folinic acid plays a vital role in the metabolism of amino acids (protein groups) and the formation of some key agents that keep the energy cycle moving, produce DNA, support the detoxification pathway and help the body absorb many other important nutrients. It is important in the processes that produce the brain chemicals (neurotransmitters) serotonin, dopamine and melatonin. Problems with folate metabolism have been associated with depression and anxiety Folinic acid along with B12 and B6 are vitamins required to metabolise an amino acid called homocysteine. Homocysteine is formed from another amino acid called methionine which is a powerful antioxidant. Folate is required for the body to make DNA and RNA and it metabolises amino acids necessary for cell division, so it is essential for the nervous system and during pregnancy but it is not recommended if you have cancer (cancer cells divide rapidly). However, Folinic Acid, as a reduced folic acid, is used in combination with other chemotherapy drugs to either enhance effectiveness, or as a "chemoprotectant."

help my son get the vitamins after he's diagnosed speech delay.....he got his first word after 3 years old...take it after breakfast or lunch....thanks iherb

This is the right kind of methyl folate to pick up energy and help the digestive process, and along with its B12 it is a wonderful way to start the morning.

I take TMG with my NMN. Kirkman also includes the B vitamins recommended when you take TMG. Getting it all in one capsule is a definite plus! 👍

I gave this as a supplement to help with the possibility of methylation problems. So far, there have been no negative side effects and there seems to be no "so big" problem to continue the class in the morning.

I usually buy the liquid one but I couldn’t find it so bought the capsules instead and I like that it had the methyl B12 and folate add witch makes it less pills to swallow and the effect was the same as the liquid one.

Feels like I have improved energy levels and it has helped with my histimime issue. Think it's contributed to lessening of chronic sinus inflammation.